IL28B polymorphism genotyping as predictor of rapid virologic response during interferon plus ribavirin treatment in hepatitis C virus genotype 1 patients

doi:10.3748/wjg.v20.i36.13146

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Sep 28, 2014 (publication date) through Feb 3, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 28, 2014; 20(36): 13146-13152
Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.13146

Table 3 Sensitivity, specificity, positive and negative predictive value of single and combined IL28B polymorphisms for achieving hepatitis C virus RNA drop ≥ 1 log at treatment week 4

IL28B polymorphisms	Sn	Sp	PPV	NPV	LR
rs8099917_TT	59%	81%	91%	36%	3.05
rs12979860_CC	29%	88%	90%	26%	2.54
rs8099917_TT or rs12979860_CC	29%	92%	93%	27%	3.82

IL: Interleukin; Sn: Sensitivity; Sp: Specificity; PPV: Positive predictive value; NPV: Negative predictive value; LR: Likelihood ratio.

Citation: Rosso C, Abate ML, Ciancio A, Strona S, Caviglia GP, Olivero A, Touscoz GA, Rizzetto M, Pellicano R, Smedile A. IL28B polymorphism genotyping as predictor of rapid virologic response during interferon plus ribavirin treatment in hepatitis C virus genotype 1 patients. World J Gastroenterol 2014; 20(36): 13146-13152
URL: https://www.wjgnet.com/1007-9327/full/v20/i36/13146.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i36.13146