Mycobacterium avium subspecies paratuberculosis in the etiology of Crohn&rsquo;s disease, cause or epiphenomenon?

doi:10.3748/wjg.v20.i36.13060

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Sep 28, 2014 (publication date) through Feb 18, 2025

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Sep 28, 2014; 20(36): 13060-13070
Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.13060

Table 3 Indirect methods for detection of Mycobacterium avium subspecies paratuberculosis: humoral and cellular mediator of immune response to Mycobacterium avium subspecies paratuberculosis

Method	Tissue analyzed	Antigen/cellular mediator	Ref.
ELISA for antibody detection
	Peripheral blood	38-kDa, 24-kDa, 18-kDa	[64]
		p35 vs p36	[65]
		14-kDa, AhpC, HSP	[66]
		MAP protoplasmic antigen	[67]
		18-kDa	[68]
		Anti-PPA	[69]
		Ptp-A	[43]
		Ptp-A, protein kinase G	[46]
ELISA for cytokine detection (proliferative assay)
	Peripheral blood lymphocytes	INFγ; IL-17	[71,72]
	Gut biopsies lymphocytes T CD4⁺	INFγ; IL-17	[73]
	Peripheral blood monocyte THP-1	TNFα	[74]

ELISA: Enzyme-linked immunosorbent assay; AhpC: Alkyl hydroperoxide reductase C; HSP: Heat shock proteins; PPA: Ptp-A protein tyrosine phosphatase; INF-γ: Interferon-gamma; IL-7: Interleukin 7; TNFα: Tumor necrosis factor alpha.

Citation: Liverani E, Scaioli E, Cardamone C, Monte PD, Belluzzi A. Mycobacterium avium subspecies paratuberculosis in the etiology of Crohn’s disease, cause or epiphenomenon? World J Gastroenterol 2014; 20(36): 13060-13070
URL: https://www.wjgnet.com/1007-9327/full/v20/i36/13060.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i36.13060