Hepatocellular carcinoma in nonalcoholic fatty liver: Role of environmental and genetic factors

doi:10.3748/wjg.v20.i36.12945

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 28, 2014; 20(36): 12945-12955
Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.12945

Table 2 Ascertained risk factors for hepatocellular carcinoma in fatty liver

Risk factors
Age
Male gender
HCV/HBV[3,30,31,36-38]
Alcohol abuse[34,35]
Severity of NAFLD/NASH[25,28-30,33,39]
Diabetes/obesity[26,31,43-46]
Iron overload[69-71]
Genetic variants (PNPLA3, APOB, TERT)[92-94,100,104,111,113,114]
Hepatic stellate cells (HSCs) activation and senescence[118,119]

HCV: Hepatitis C virus; HBV: Hepatitis B virus; NAFLD: Nonalcoholic fatty liver disease; NASH: Nonalcoholic steatohepatitis; PNPLA3: Patatin-like phospholipase domain-containing protein 3; APOB: Apolipoprotein B; TERT: Telomerase reverse transcriptase.

Citation: Dongiovanni P, Romeo S, Valenti L. Hepatocellular carcinoma in nonalcoholic fatty liver: Role of environmental and genetic factors. World J Gastroenterol 2014; 20(36): 12945-12955
URL: https://www.wjgnet.com/1007-9327/full/v20/i36/12945.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i36.12945