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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Sep 28, 2014; 20(36): 12945-12955
Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.12945
Table 2 Ascertained risk factors for hepatocellular carcinoma in fatty liver
Risk factors
Age
Male gender
HCV/HBV[3,30,31,36-38]
Alcohol abuse[34,35]
Severity of NAFLD/NASH[25,28-30,33,39]
Diabetes/obesity[26,31,43-46]
Iron overload[69-71]
Genetic variants (PNPLA3, APOB, TERT)[92-94,100,104,111,113,114]
Hepatic stellate cells (HSCs) activation and senescence[118,119]
HCV: Hepatitis C virus; HBV: Hepatitis B virus; NAFLD: Nonalcoholic fatty liver disease; NASH: Nonalcoholic steatohepatitis; PNPLA3: Patatin-like phospholipase domain-containing protein 3; APOB: Apolipoprotein B; TERT: Telomerase reverse transcriptase.