Hepatoid adenocarcinoma of the colon in a patient with inflammatory bowel disease

Figure 2 Colectomy specimen showed two synchronous tumors with divergent histologic differentiation. A: The larger tumor was poorly differentiated and composed of sheets of polygonal-shaped cells with granular eosinophilic cytoplasm, centrally located nuclei and prominent nucleoli (hematoxylin and eosin staining, × 40 magnification); B: Larger tumor at × 200 magnification, inset shows immunostaining for alpha-fetoprotein; C: The second tumor demonstrated a more typical colonic morphologic differentiation, characterized by infiltrating submucosal glands (hematoxylin and eosin staining, × 40 magnification); D: Second tumor at × 200 magnification.