Pharmacological interventions for improved colonic anastomotic healing: A meta-analysis

Table 4 Studies on matrix metalloproteinase inhibitors in colonic anastomotic healing

Study	Compound	Species	Sex	Sample size1	Dosage (mg/kg)	Route	Test	Test day	Effect2
de Hingh et al[79]	BB-94	Rat	Male	60	30	IP	BPR/BST	1	NS/NS
							BPR/BST	3	↑54/↑27
							BPR/BST	7	NS/NS
Kiyama et al[80]	BE16627B	Rat	Male	21	About 10	SC	BPR	4	↑28
Pasternak et al[81]	Doxycycline	Rat	Male	40	NA	LO	BST	3	↑17
Siemonsma et al[82]	Doxycycline	Rat	Male	80	About 40	SC	BPR/BST	1	NS/NS
						SC	BPR/BST	3	↑93/↑27
						PO	BPR/BST	3	↑36/NS
						SC	BPR/BST	5	NS/NS
Syk et al[7]	BB-1101	Rat	Male	48	30	SC	BST	1/3/7	NS/↑48/NS
Ågren et al[8]	AG3340	Rat	Male	120	10	SC	BST	3	↑47
	GM6001	Rat	Male		10/100	SC	BST	3	↑79/↑88

¹Total number of animals;

²↑% increase (P < 0.05) or ↓% decrease (P < 0.05) vs controls; BPR: Bursting pressure; BST: Breaking strength; IP: Intraperitoneal; LO: Local; NA: Not applicable; SC: Subcutaneous; NS: Not statistically significant.