Pharmacological interventions for improved colonic anastomotic healing: A meta-analysis

Table 2 Studies on the hormones erythropoietin and growth hormone, and the growth factor insulin-like growth factor-1 in colonic anastomotic healing

Study	Compound	Species	Sex	Sample size1	Dosage2	Route	Test	Test day	Effects3
Faruquzzaman et al[34]	EPO	Guinea pig	Male	20	500	SC	BPR	7	NS
Fatouros et al[19]	EPO	Rat	Male	30	500	SC	BST	7	↑37
Kaemmer et al[35]	EPO	Rat	Male	20	5000	SC	BPR	3/5	NS/↑82
Moran et al[36]	EPO	Rat	Male	20	500	SC	BPR	7	NS
Ozel Turkcu et al[37]	EPO	Rat	Male	16	500	IM	BPR	7	↑93
Adas et al[38]	GH	Rat	Male	20	2.0	SC	BPR	4	↑16
Christensen et al[39]	GH	Rat	Female	72	2.0	SC	BPR	2/4/6	↑104/↑232/NS
Christensen et al[40]	GH	Rat	Female	72	2.0	SC	BPR	2/4/6	↑55/NS/NS
Christensen et al[41]	GH	Rat	Female	50	0.125/0.5/2.0/8.0	SC	BPR	4	NS/NS/↑270/↑430
Christensen et al[42]	GH	Rat	Female	36	2.04/5/6	SC	BST	4	NS/↑34/↑59
Karahasanoglu et al[43]	GH	Rat	Male	20	2.0	SC	BPR	4	↑11
Egger et al[44]	IGF-1	Rat	Male	76	1.0	IP	BPR	2/4/6	↑62/↑67/↑61
Mantzoros et al[45]	IGF-1	Rat	Female	40	2.0	IP	BPR	7	↑25
Petersen et al[46]	IGF-1	Rat	Female	26	about 2.5	SC	BST	3	NS
Zacharakis et al[47]	IGF-1	Rat	Male	40	2.0	IP	BPR	7	↑29

¹Total number of animals;

²EPO: IU/kg; GH: mg/kg; IGF-1: mg/kg;

³↑% increase (P < 0.05) or ↓% decrease (P < 0.05) vs controls; ⁴Preoperative; ⁵Postoperative; ⁶Preoperative and postoperative. BPR: Bursting pressure; BST: Breaking strength; EPO: Erythropoietin; GH: Growth hormone; IGF-1: Insulin-like growth factor-1; IM: Intramuscular; IP: Intraperitoneal; SC: Subcutaneous; NS: Not statistically significant.