Pharmacological interventions for improved colonic anastomotic healing: A meta-analysis

Table 1 Studies on the immunomodulators iloprost and tacrolimus in colonic anastomotic healing

Study	Compound	Species	Sex	Sample size1	Dosage (mg/kg)	Route	Test	Test day	Effects2
Bostanoğlu et al[12]	Iloprost	Rat	Male	40	0.002	IP	BPR	3/7	↑82/NS
Galanopoulos et al[13]	Iloprost	Rat	Male	40	0.002	IP	BPR	4/8	↑56/NS
Vasiliadis et al[14]	Iloprost	Rat	Male	20	0.002	IP	BPR	5/8	↑78/NS
Kiyama et al[15]	Tacrolimus	Rat	Male	42	0.01/0.1/1.0	SC	BPR	4	↑23/↑33/↑27
Raptis et al[16]	Tacrolimus	Rat	Male	40	0.1	SC	BPR	4/8	↑60/↑43
Schäffer et al[17]	Tacrolimus	Rat	Male	24	2.0	SC	BPR	5	NS

¹Total number of animals;

²↑% increase (P < 0.05) or ↓% decrease (P < 0.05) vs controls. NS: Not statistically significant; BPR: Bursting pressure; IP: Intraperitoneal; SC: Subcutaneous.