Parameters of a severe disease course in ulcerative colitis

Table 2 Independent parameters associated with a severe course of ulcerative colitis, predicting the risk for subsequent necessity of immunosuppressive therapy (multivariate analysis)

Parameter	OR	95%CI	P value
Age at diagnosis	0.981 (per year)	0.967-0.995	0.009
Gender (female)	1.3	0.9-2.0	0.156
Steroid therapy at diagnosis	2.4	1.6-3.7	< 0.001
Hospitalisation at diagnosis	2.5	1.5-4	< 0.001
Extent of the disease			< 0.001
Proctitis	1
Procto-sigmoiditis	3.5	1.4-8.6	0.007
Left-sided colitis	5.3	1.6-15.3	0.002
Pancolitis	6.1	2.1-17.5	0.001
Result of steroid therapy			< 0.001
No steroids	1
Remission	5.2	1.4-20.3	0.016
Response	15.3	4.7-50	< 0.001
Steroid-dependent	50.8	15.2-170	< 0.001
Steroid-refractory	34.8	10.5-114.8	< 0.001