Role of ERK-MAPK signaling pathway in pentagastrin-regulated growth of large intestinal carcinoma

Table 5 Comparison of protein, mRNA and phosphorylation levels of extracellular signal-regulated protein kinase 1/2 and K-ras between the experimental groups (mean ± SD) and control group

Group	n	ERK1/2			K-ras
		mRNA	Protein	p-ERK1/2	mRNA	Protein	p-K-ras
Control group	5	0.76 ± 0.04	0.56 ± 0.05	0.32 ± 0.02	0.54 ± 0.08	0.56 ± 0.04	0.31 ± 0.05
Pentagastrin group	5	0.79 ± 0.05	0.60 ± 0.04	0.43 ± 0.04a	0.59 ± 0.06	0.57 ± 0.04	0.45 ± 0.06a
Proglumide group	5	0.74 ± 0.06	0.55 ± 0.07	0.31 ± 0.02c	0.53 ± 0.05	0.55 ± 0.04	0.27 ± 0.06c
Pentagastrin + proglumide group	5	0.77 ± 0.05	0.58 ± 0.05	0.36 ± 0.01c	0.55 ± 0.06	0.57 ± 0.04	0.35 ± 0.04c

^aP < 0.05 vs control group;

^cP < 0.05 vs pentagastrin group. ERK1/2: Extracellular signal-regulated protein kinase 1/2.