Occupational exposures and colorectal cancers: A quantitative overview of epidemiological evidence

Table 4 Pooled estimates for rectal cancer, by industrial branch and study design

ISIC	Industrial branch	Cohort studies		Other study design2		All
		(95%CI)		(95%CI)		(95%CI)
		Crude RR	Adjusted RR3	Crude RR	Adjusted RR3	Crude RR	Adjusted RR3
1	Crop and animal production	0.86	-	1.5	-	0.97	-
		(0.74-1.00)		(0.55-2.45)		(0.67-1.41)
3	Fishing and aquaculture1	1.05	-	-	-	1.05	-
		(0.86-1.25)				(0.87-1.26)
10	Manufacture of food products1	0.75	-	-	-	0.75	-
		(0.33-1.70)				(0.33-1.70)
11	Manufacture of beverages	1.45		-	-	1.45	-
		(1.13-1.85)				(1.13-1.85)
15	Manufacture of leather and related products	2.06	-	-	-	2.06	-
		(0.36-3.76)				(0.91-4.65)
16	Manufacture of wood and of products of wood and cork1	0.4	-		-	0.4	-
		(0.06-2.53)				(0.06-2.53)
19	Manufacture of coke and refined petroleum products1	2.49	-	-	-	2.49	-
		(1.02-6.07)				(1.02-6.07)
20	Manufacture of chemicals and chemical products	1.22	-	-	-	1.22	-
		(0.62-2.41)				(0.62-2.41)
22	Manufacture of rubber and plastics products	0.82	-	-	-	0.82	-
		(0.55-1.22)				(0.55-1.22)
23	Manufacture of other non-metallic mineral products1	1.25	-	-	-	1.25	-
		(0.61-2.55)				(0.61-2.55)
24	Manufacture of basic metals	1.25	-		-	1.25	-
		(0.77-2.04)				(0.77-2.04)
29	Manufacture of motor vehicles	1.7	-	-	-	1.7	-
		(0.53-5.43)				(0.53-5.43)
31	Manufacture of furniture	1.32	-	-	-	1.32	-
		(0.93-1.88)				(0.93-1.88)
33	Repair and installation of machinery and equipment	0.76	-	-	-	0.76	-
		(0.42-1.38)				(0.42-1.38)
72	Scientific research and development1	1.1	-	-	-	1.1	-
		(0.26-1.95)				(0.52-2.34)
-	All industrial branches combined	1.15	1.15	1.5	1.5	1.15	1.15
		(0.99-1.34)	(0.99-1.34)	(0.55-2.45)	(0.55-2.45)	(0.99-1.34)	(0.99-1.34)
	Heterogeneity (I2)	53.8%		-		53.8%

¹Only one study;

²Case-control studies and meta-analyses;

³Duval and Tweedie trim and fill method. RR: Relative risk; ISIC: International Standard Industrial Classification.