Early-onset colorectal cancer: A sporadic or inherited disease?

Table 1 Early onset colorectal cancer: Comparison of published studies

Author	Year	Patient age	Youg onset CRC/overall CRC n (%)	5-yr survival	Tumour site	Advanced stage	Adverse histological features (mucinous and poorly differentiated)
Lee et al[24]	1994	< 40	62/2000	Dukes C 40%	Not specified	71%1	Not specified
			-3.1	Dukes D 7%
Fante et al[25]	1997	< 40	14/1298	70%	Left sided 63%	57%1	21.4% mucinous
			-1.1
Pitluk et al[26]	1983	< 40	31/861	22%	Left	Not specified	Not specified
			-3.6
Minardi et al[27]	1998	< 40	37	26%	Left 51.3%	59%1	58% mucinous
Domergue et al[28]	1988	< 40	93/2600	30%	Left 74% (rectal 55)	80%1	40% poorly differentiated
			-3.6
Palmer et al[29]	1991	< 40	105		Left sided	63%1	Not specified
Behbehani et al[30]	1985	< 40	47 vs 525	23%	Left sided 58%	Not specified	26% mucinous
							21% poorly differentiated
							Parramore et al[20]	1998	< 40	36/418 (8.6)	Not specified	Not specified	78%1	28% poorly differentiated
26% mucinous
Soliman et al[16]	1997	< 40	572/1608 (35.6)	Not specified	Rectal > 50%	Not specified	30.6% mucinous
Yilmazlar et al[17]	1995	< 40	46/237 (19.4)	Not specified	Left sided 80%	76%1	48%
Isbister et al[21]	1990	< 40	131/2420 (5.4)	Not specified	Not specified	Not specified	Not specified
Adloff et al[22]	1986	< 40	32/1037 (3)	Not specified	Not specified	Not specified	Not specified
Safford et al[15]	1981	< 40	140/819 (17.1)	Not specified	Not specified	Not specified	Not specified
Moore et al[23]	1984	< 40	62/1909	Not specified	Left sided 58%	Not specified	32.3% mucinous 98% poorly differentiated
			-3.2
Mäkelä et al[18]	2010	< 40	59/1272	58%	Left sided 42%	Not specified	Not specified
			-4.6
Torsello et al[19]	2008	< 40	58/1340	48.9%	Left sided 82.7%	46.5%2	14% poorly differentiated
			-4.2				26% mucinous
Chang et al[53]	2012	< 40	55/1160	53%	Left sided 80%	63%	24% mucinous
			-4.7
Myers et al[31]	2013	< 50	49/437	Not specified	Left sided 62.1%	53%2	12% poorly differentiated
			-11.2				19% mucinous

¹Dukes classification, stages C and D;

²Tumor node metastasis staging, stages III and IV. CRC: Colorectal cancer.