Immune reaction and colorectal cancer: Friends or foes?

doi:10.3748/wjg.v20.i35.12407

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Sep 21, 2014 (publication date) through Nov 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2014; 20(35): 12407-12419
Published online Sep 21, 2014. doi: 10.3748/wjg.v20.i35.12407

Table 1 summarizes main cell types involved in immune reaction during colorectal cancer disease

Immune cell type: phenotype and description	Effect on colorectal cancer prognosis
CD8+CD45RO+ T cells: memory cytotoxic T cells, associated with a T helper 1 orientation	Favorably influencing relapse-free, progression-free and overall survival
FOXP3+CD25+CD4+ T cells: Regulatory T cells with suppressive effect on effector cytotoxic lymphocytes	Unfavorably influencing relapse-free and overall survival
CD14+CD163-IL10^high M1 macrophages: classically activated macrophages	Favorably influencing prognosis by enhancing Th1-type antitumor immune response
CD14+CD163+IL12^high M1 macrophages: classically activated macrophages	Unfavorably influencing prognosis by exerting immunosuppressive effect and enhancing Th2-type response
Lin-HL-ADR-CD11b+CD33+ cells: Myeloid-derived suppressor cells	Unfavorably influencing prognosis by promoting metastatic spread

TH: Helper T cell; IL: Interleukin.

Citation: Formica V, Cereda V, Nardecchia A, Tesauro M, Roselli M. Immune reaction and colorectal cancer: Friends or foes? World J Gastroenterol 2014; 20(35): 12407-12419
URL: https://www.wjgnet.com/1007-9327/full/v20/i35/12407.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i35.12407