Abnormal β-catenin immunohistochemical expression as a prognostic factor in gastric cancer: A meta-analysis

Table 2 Stratified analysis of pooled hazard ratios

Subgroup analysis	Studies (n)	Pooled HR (95%CI)		P value	Heterogeneity
		Fixed	Random		I2(%)	P value
Definition
Abnormal	5		2.12 (1.31-3.42)	0.002	48	0.10
Nucleus accumulation	5		1.66 (0.90-3.06)	0.270	83	< 0.0001
Loss of membrane expression	5		1.61 (0.88-2.96)	0.0006	75	0.003
Cytoplasmic expression	2	1.52 (1.05-2.19)		0.020	0	0.56
Study location
Asia	9		1.86 (1.23-2.80)	< 0.0001	81	< 0.00001
Other regions	6	1.70 (1.33-2.19)		< 0.0001	9	0.36
No. of patients
> 100	9		1.82 (1.26-2.64)	0.002	81	< 0.00001
≤ 100	6	1.81 (1.31-2.49)		0.0003	3	0.40
Publication year
> 2000	12		1.83 (1.33-2.52)	< 0.00001	76	< 0.00001
≤ 2000	3	2.07 (1.13-3.81)		0.020	0	0.76
Antibody source
BD transduction	3		1.73 (0.64-4.69)	0.280	90	< 0.0001
Transduction lab	3		2.36 (1.06-5.27)	0.040	75	0.02
Santa cruz	3	1.53 (1.18-1.97)		0.001	44	0.17
Other labs	6	1.75 (1.37-2.25)		< 0.00001	7	0.37