Abnormal β-catenin immunohistochemical expression as a prognostic factor in gastric cancer: A meta-analysis

Table 1 Baseline characteristics and methodological assessment of the included trials

Ref.	Year	Study location	Patient (M/F)	Luaren classfication			Antibody source	Definition ofβ-catenin expression1	NOS
				Intestinal	Diffuse	Mixed
Ayed-Guerfali et al[13]	2013	Tunisia	80 (45/35)	48	32		Santa Cruz	Normal/abnormal expression	7
Sereno et al[19]	2012	Spain	44 (33/11)	22	13	9	Transduction Laboratories	Normal/abnormal expression	6
Hou et al[20]	2012	China	158 (105/53)				Santa Cruz	Normal/abnormal expression	6
Liu et al[22]	2012	China	134 (90/44)				Santa Cruz	Nuclear expression	5
Sun et al[21]	2012	China	58 (49/9)				Santa Cruz	Normal/abnormal expression	5
Ryu et al[23]	2012	South Korea	276 (NA)				BD Biosciences	Normal/abnormal expression	7
Retterspitz et al[24]	2010	Germany	94 (46/48)	0	88	6	BD Transduction	Membranous expression	8
Kim et al[25]	2010	South Korea	117 (81/36)	40	75	2	BD Transduction	Nuclear expression	8
Czyzewska et al[26]	2010	Poland	91 (62/29)	61	30	0	Novocastra Laboratories Ltd	Membranous expression	6
Zali et al[28]	2009	Iran	56 (38/18)	35	16	5	Research Diagnostic	Normal/abnormal expression	8
Kim et al[29]	2009	South Korea	598 (396/202)				BD Biosciences	Nuclear expression	6
Bazas et al[30]	2008	Ukraine	150 (89/61)	117	33	0	Dako Cytomation	Cytoplasmic expression	8
Koriyama et al[31]	2007	Japan	149 (NA)	99	50	0	Transduction Laboratories	Normal/abnormal expression	8
Jung et al[32]	2007	South Korea	111 (NA)	44	67	0	Transduction Laboratories	Nuclear expression	9
Nabais et al[33]	2003	Portugal	97 (NA)	28	51	18	Transduction Laboratories	Nuclear and cytoplasmic expression	7
Zhou et al[34]	2002	China	163 (123/40)	108	40	15	Maxim Biotech Inc.	Normal/abnormal expression	8
Woo et al[14]	2001	South Korea	303 (205/98)	116	158	29	Transduction Laboratories	Membranous expression	9
Shun et al[35]	2001	Taiwan	53 (NA)	30	23		Transduction Laboratories	Normal/abnormal expression	6
Grabsch et al[36]	2001	Germany	401 (NA)	255	112	34	Transduction Laboratories	Nuclear and cytoplasmic expression	6
Joo et al[37]	2000	South Korea	65 (38/27)	28	25	12	Zymed Laboratories	Normal/abnormal expression	7
Karatzas et al[38]	2000	Greece	36 (NA)	24	12		Transduction Laboratories	Normal/abnormal expression	6
Ohene-Abuakwa et al[39]	2000	United Kingdom	41 (NA)	28	7	6	Transduction Laboratories	Normal/abnormal expression	7
Ramesh et al[15]	1999	United Kingdom	40 (NA)				Affinity Research Products Ltd	Normal/abnormal expression	8
Jawhari et al[40]	1997	England	89 (62/27)	63	24	2	Affinity Research Products Ltd	Normal/abnormal expression	7

¹Different β-catenin location in gastric cancer. NA: Not available; M/F: Male/Female; NOS: Newcastle-Ottawa Quality Assessment Scale.