Endoscopic features suggesting gastric cancer in biopsy-proven gastric adenoma with high-grade neoplasia

Table 1 Baseline characteristics and endoscopic features in the adenoma and carcinoma groups n (%)

	Adenoma group	Cancer group	Univariate analysis	Multivariate analysis
	(n = 52)	(n = 60)	P value	OR (95%CI)	P value
Age (yr)	65.2 ± 10.3	65.5 ± 10.2	0.879
Gender			0.270
Male	35 (67.3)	46 (76.7)
Female	17 (32.7)	14 (23.3)
Lesion size	16.1 ± 10.7	18.1 ± 11.3	0.347
Tumor location (longitudinal)			0.327
Upper third	1 (1.9)	4 (6.7)
Middle third	5 (9.6)	3 (5.0)
Lower third	46 (88.5)	53 (88.3)
Tumor location (horizontal)			0.308
Anterior wall	11 (21.2)	12 (20.0)
Lesser curvature	16 (30.8)	26 (43.3)
Posterior wall	7 (13.5)	10 (16.7)
Greater curvature	18 (34.6)	12 (20.0)
Size (cm)			0.542
< 1	10 (19.2)	11 (18.3)
1-1.9	28 (53.8)	26 (43.3)
2-2.9	10 (19.2)	14 (23.3)
≥ 3	4 (7.7)	9 (15.0)
Macroscopic type			0.121
Elevated	24 (46.2)	18 (30.0)
Flat	17 (32.7)	20 (33.3)
Depressed	11 (21.2)	22 (36.7)
Surface configuration
Nodular change	26 (50.0)	38 (63.3)	0.155
Red color change	27 (51.9)	46 (76.7)	0.006	2.682 (1.061-6.784)	0.037
Mucosal ulceration	5 (9.6)	17 (28.3)	0.013	3.562 (1.056-12.021)	0.041
Interval between biopsy and ESD (d)	29.5 ± 17.1	29.0 ± 15.1	0.886

ESD: Endoscopic submucosal dissection.