McGill Brisbane Symptom Score for patients with resectable pancreatic head adenocarcinoma

Table 4 Results of multivariable Cox regression analysis

Variable		HR	Coef.	P value	95%CI for HR
Model 1 (n = 83) Stratified by chemotherapy status
	High MBSS	2.63	0.969	0.001	1.49	4.67
	Age	1.03	0.030	0.027	1.00	1.06
	Tumor size (cm)	1.21	0.189	0.101	0.96	1.51
Model 2 (n = 74) Interaction between MBSS group and chemotherapy status
Low MBSS	Chemotherapy	1.29	0.256	0.625	0.46	3.61
	Age	1.03	0.032	0.024	1.00	1.06
	Tumor size (cm)	1.16	0.149	0.190	0.93	1.45
No Chemotherapy	High MBSS	4.14	1.421	0.007	1.48	11.64
Chemotherapy	High MBSS	2.11	0.740	0.033	1.06	4.17

Margin status and gender did not significantly improve the prediction model. Measure of interaction on multiplicative scale: HR= 0.51, (95%CI: 0.15-1.74; high MBSS vs low MBSS, P = 0.28. MBSS: McGill Brisbane Symptom Score.