Noninvasive assessment of liver fibrosis in patients with chronic hepatitis B

Table 2 Performance of transient elastography for identification of significant fibrosis (≥ F2) and cirrhosis (F4) in patients with hepatitis B

Ref.	Year	Patients (n)	Diagnosis for≥F2				Diagnosis for F4
			Patients (%)	AUROC	Cutoff (kPa)	Se/Sp (%)	Patients (%)	AUROC	Cutoff (kPa)	Se/Sp (%)
Oliveri et al[39]	2008	188	26	0.97	7.5	94/88	20	0.97	11.8	86/96
Marcellin et al[40]	2009	173	50	0.81	7.2	70/83	8	0.93	11.0	93/87
Chan et al[41]	2009	161	-	-	-	-	25	0.93	12.0-13.42	98/75
Degos et al[32]	2010	284	42	0.78	5.2	89/38	10	0.85	12.9	52/93
Wong et al[22]	2010	156 + 82	68	0.80	9.0-12.02	54/99	23	-	-	-
1Miailhe et al[42]	2011	57	61	0.85	5.9	81/87	20	0.96	9.4	92/94

¹Study subjects were coinfected with human immunodeficiency virus;

²Adapted to ALT values. AUROC: Area under the receiver operating characteristic curve; Se: Sensitivity; Sp: Specificity.