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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Sep 14, 2014; 20(34): 12031-12038
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12031
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12031
Ref. | Year | Patients (n) | Diagnosis for≥F2 | Diagnosis for F4 | ||||||
Patients (%) | AUROC | Cutoff (kPa) | Se/Sp (%) | Patients (%) | AUROC | Cutoff (kPa) | Se/Sp (%) | |||
Originally for patients with HCV | ||||||||||
Fibrotest (includes α2-macroglobulin, haptoglobin, apolipoprotein A1, bilirubin, and GGT) | ||||||||||
Sebastiani et al[20] | 2007 | 110 | 68 | 0.85 | F2 | 81/90 | 20 | 0.76 | F4 | 56/96 |
1Bottero et al[21] | 2009 | 108 | 56 | 0.77 | 0.48 | 70/72 | 15 | 0.87 | 0.73 | 75/85 |
Forns index (includes age, platelet count, cholesterol, and GGT) | ||||||||||
Sebastiani et al[20] | 2007 | 110 | 68 | 0.63 | 4.20 | 58/78 | 20 | - | - | - |
Wong et al[22] | 2010 | 156 + | 75 | 0.70 | 5.20 | 28/91 | 26 | - | - | - |
82 | 59 | 0.72 | 8.40 | 43/93 | 20 | |||||
1Bottero et al[21] | 2009 | 108 | 56 | 0.72 | - | - | 15 | 0.81 | - | - |
APRI (includes AST and platelet count) | ||||||||||
Sebastiani et al[20] | 2007 | 110 | 68 | 0.72 | 0.50 | 71/87 | 20 | 0.64 | 2.00 | 43/85 |
Kim et al[23] | 2010 | 668 | 79 | 0.70 | - | - | 34 | 0.73 | - | - |
1Bottero et al[21] | 2009 | 108 | 56 | 0.73 | - | - | 15 | 0.76 | - | - |
FIB-4 (includes age, AST, ALT, and platelet count) | ||||||||||
Kim et al[23] | 2010 | 668 | 79 | 0.86 | 1.00 | 91/73 | 34 | 0.93 | 1.60 | 88/84 |
1Bottero et al[21] | 2009 | 108 | 56 | 0.74 | - | - | 15 | 0.80 | - | - |
Fibrometer (includes age, platelet count, PT index, AST, α2-macroglobulin, hyaluronate, and urea) | ||||||||||
1Bottero et al[21] | 2009 | 108 | 56 | 0.74 | 0.46 | 73/68 | 15 | 0.89 | 0.83 | 81/85 |
Originally for patients with HBV | ||||||||||
Hui score (includes body mass index, bilirubin, albumin, and platelet count) | ||||||||||
Hui et al[25] | 2005 | 235 | 25 | 0.79 | 0.15 | 88/50 | - | - | - | - |
Zeng score (includes age, α2-macroglobulin, hyaluronate, and GGT) | ||||||||||
Zeng et al[26] | 2005 | 372 | 58 | 0.77 | 3.00 | 98/28 | - | - | - | - |
- Citation: Enomoto M, Morikawa H, Tamori A, Kawada N. Noninvasive assessment of liver fibrosis in patients with chronic hepatitis B. World J Gastroenterol 2014; 20(34): 12031-12038
- URL: https://www.wjgnet.com/1007-9327/full/v20/i34/12031.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i34.12031