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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Sep 14, 2014; 20(34): 12031-12038
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12031
Table 1 Performance of serum fibrosis markers for identification of significant fibrosis (≥ F2) and cirrhosis (F4) in patients with hepatitis B
Ref.YearPatients (n)Diagnosis forF2
Diagnosis for F4
Patients (%)AUROCCutoff (kPa)Se/Sp (%)Patients (%)AUROCCutoff (kPa)Se/Sp (%)
Originally for patients with HCV
Fibrotest (includes α2-macroglobulin, haptoglobin, apolipoprotein A1, bilirubin, and GGT)
Sebastiani et al[20]2007110680.85F281/90200.76F456/96
1Bottero et al[21]2009108560.770.4870/72150.870.7375/85
Forns index (includes age, platelet count, cholesterol, and GGT)
Sebastiani et al[20]2007110680.634.2058/7820---
Wong et al[22]2010156 +750.705.2028/9126---
82590.728.4043/9320
1Bottero et al[21]2009108560.72--150.81--
APRI (includes AST and platelet count)
Sebastiani et al[20]2007110680.720.5071/87200.642.0043/85
Kim et al[23]2010668790.70--340.73--
1Bottero et al[21]2009108560.73--150.76--
FIB-4 (includes age, AST, ALT, and platelet count)
Kim et al[23]2010668790.861.0091/73340.931.6088/84
1Bottero et al[21]2009108560.74--150.80--
Fibrometer (includes age, platelet count, PT index, AST, α2-macroglobulin, hyaluronate, and urea)
1Bottero et al[21]2009108560.740.4673/68150.890.8381/85
Originally for patients with HBV
Hui score (includes body mass index, bilirubin, albumin, and platelet count)
Hui et al[25]2005235250.790.1588/50----
Zeng score (includes age, α2-macroglobulin, hyaluronate, and GGT)
Zeng et al[26]2005372580.773.0098/28----