Manifestations of gastrointestinal plasmablastic lymphoma: A case series with literature review

Table 1 Literature review and case study summary of demographic, clinical presentation, treatment and outcomes of plasmablastic lymphoma of gastrointestinal tract

No.	Study	Year	Age/sex	Tumor location	HIV status	GI S/Sx	B symptoms	Chemotherapeutic treatment	Response	Outcome
1	Mani et al[6]	2008	40/M	Esophagus, stomach	+	Progressive odynophagia	WL, F, NS	LACE	Remission	Alive at 6 mo
2	Cha et al[7]	2010	60/M	Small intestine	-	Dyspnea, melena	WL +	CHOP	PR	Relapse, alive at 24 mo
3	Brahmania et al[18]	2011	59/M	Ano-rectal	-	Painless rectal bleeding	NR	CHOP	Remission	Alive at 5 yr
4	Mihaljevic et al[17]	2012	60/M	Stomach	-	Melena1	WL +	CHOP	UR	DOD after one cycle of CHOP
5	Hashimoto et al[15]	2012	70/F	Stomach	-	Melena	NR	CHOP, VP 16, ifosfamide, carboplatin	UR	Died during treatment
6	Chapman-Fredricks et al[14]	2012	46/F	Stomach	+	N/V, diarrhea, melena	NR	EPOCH	NL	NL
7	Bahari et al[11]	2012	17/F	Small intestine	ND	Diarrhea, distention1	F+	NL	NL	DOD before diagnosis made
8	Pruneri et al[10]	1998	53/F	Stomach	-	Postprandial fullness, stomach ache	F+	ProMACE-cytaBOM	Remission	Alive at 19 mo
9	Rajagopal et al[9]	2006	35/M	Ano-rectal	+	Rectal bleeding, tenesmus, constipation1	WL +	CHOP	Remission	Alive at 5 mo
10	Wang et al[8]	2012	55/M	Small intestine	-	Distention, vomiting, anorexia1	WL +	CHOP	UR	DOD at 1.5 mo
11	Hatanaka et al[19]	2010	75/M	Cecum	-	NL1	F +	NL	NL	NL
12	Lim et al[16]	2009	47/F	Ano-rectal	+	Anal bleeding, pain, fistula for 1 yr	NR	CHOP	Received 3 cycles of chemotherapy, status unknown	NL
13	Marques et al[13]	2013	82/F	Stomach	-	Melena, epigastric pain, abdominal fullness	WL +	CHOP	UR	DOD after 1 cycle of chemotherapy
14	Mansoor et al[12]	2012	77/F	Cecum, colon	-	Recal bleeding, diarrhea, vomiting1	WL +	NL	UR	DOD 3 wk after presentation
Case 1	Luria et al	Current case	40/M	Rectal	+	Hemorr-hoids like sensations	WL +	EPOCH	PR	Relapsed PBL in pelvic, abdomen, bladder 1 yr after PBL diagnosis - loss of follow after it
Case 2	Luria et al	Current case	64/M	Sigmoid colon	NR	Bloody diarrhea	NR	CHOP-R, Auto-HSCT	CR	Alive at 44/35 mo
Case 3	Luria et al	Current case	41/M	Terminal ileum	NR	Abdominal pain, diarrhea, 35-pound weight loss	WL +	Hyper-CVAD + Velcade	UR	Progressive, bladder mass, hepatic metastases, DOD, 17 mo after PBL diagnosed
Case 4	Luria et al	Current case	65/M	Terminal ileum and cecum	-	Acute bowel obstruction	NA	Hyper-CVAD + rituximab, auto-HSCT	UR	CR for PBL, but developed tAML and DOD 2 mo after tAML diagnosed and 25 mo after PBL diagnosed

¹Accompany abdominal pain; 44/35: 44 mo after diagnosis and 35 mo post transplant; +: Positive; -: Negative; ND: Not done; GI S/Sx: GI tract symptoms and signs; WL: Weight loss; F: Fever; NS: Night sweats; NR: None reported; NL: None listed; CHOP: Cyclophosphamide, hydroxydaunorubicin, oncovin, prednisone; CHOP-R: Cyclophosphamide, doxorubicin, vincristine, prednisone-rituximab; LACE: Lomustine, cytarabine, cyclophosphamide, etoposide; EPOCH: Etoposide, vincristine, doxorubicin, cyclophosphamide, and prednisone; proMACE-cytaBOM: Cyclophosphamide, doxorubicin, etoposide cytozar, bleomycin, vincristine, methotrexate and prednisone; Hyper-CVAD: Fractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone; PR: Partial remission; UR: Unresponsive to therapy; NA: Not Applicable; DOD: Died of disease.