S-1-based vs non-S-1-based chemotherapy in advanced gastric cancer: A meta-analysis

Table 2 Comparison of toxicity between S-1-based chemotherapy and non-S-1-based chemotherapy

Toxicity	Number of Trials	Incidence of toxicity (%)		RR (95%CI)	P value
		S-1 Arm	Non-S-1 Arm
Hematologic
Anemia	6	14.01	14.86	1.150 (0.720-1.837)	0.560
Neutropenia	6	17.54	24.80	1.043 (0.451-2.413)	0.922
Thrombocytopenia	4	3.91	5.22	0.736 (0.499-1.085)	0.121
Leukopenia	6	8.87	9.15	1.334 (0.524-3.397)	0.546
Febrile neutropenia	3	0.86	3.54	0.225 (0.126-0.515)	0.000
Neutropenic infection	3	0.67	0.39	1.450 (0.476-4.424)	0.513
Nonhematologic
Fatigue	6	8.67	8.37	1.041 (0.788-1.375)	0.777
Vomiting	5	4.29	5.61	0.769 (0.530-1.114)	0.164
Nausea	6	5.91	7.38	0.805 (0.583-1.111)	0.187
Diarrhea	6	5.24	3.54	1.288 (0.590-2.813)	0.525
Abdominal pain	2	4.00	2.76	1.469 (0.925-2.335)	0.103
Anorexia	6	7.44	6.99	1.074 (0.790-1.461)	0.647
Weight decreased	2	2.00	3.25	0.625 (0.369-1.061)	0.082
Stomatitis/mucosal inflammation	4	1.53	11.81	0.230 (0.060-0.878)	0.032
Liver function	3	0.86	0.69	1.221 (0.481-3.103)	0.674
Neuropathy, peripheral	5	0.67	0.89	0.724 (0.274-1.915)	0.515
Alopecia	2	0.38	0.30	1.205 (0.300-4.840)	0.792
Palmar-plantar erythrodysesthesia	4	0.38	0.59	0.719 (0.241-2.150)	0.555

RR: Relative risk.