Association between serum alpha-fetoprotein levels and fatty liver disease: A cross-sectional study

Table 1 Comparison of clinical characteristics between the subjects with and without fatty liver disease

	Without FLD1	With FLD2	t value	P value
Age (yr)	45.0 (39.0–53.0)	48.0 (41.0–55.0)	8.248	< 0.001
Gender (male/female, n)	3748/3451	2132/469	712.0053	< 0.0013
Body mass index (kg/m2)	22.92 (2.71)	26.72 (2.72)	61.262	< 0.001
Waist circumference (cm)	80.4 (8.9)	92.7 (7.7)	58.903	< 0.001
Systolic blood pressure (mmHg)	123.8 (17.0)	134.9 (16.1)	29.053	< 0.001
Diastolic blood pressure (mmHg)	75.4 (10.9)	83.3 (10.5)	31.739	< 0.001
Alanine aminotransferase (U/L)	17.0 (13.0–24.0)	29.0 (21.0–43.0)	42.1944	< 0.0014
Aspartate aminotransferase (U/L)	20.0 (17.0–24.0)	23.0 (19.0–29.0)	25.3394	< 0.0014
Gamma-glutamyltransferase (U/L)	19.0 (13.0–31.0)	39.0 (25.0–64.0)	39.8464	< 0.0014
Direct bilirubin (μmol/L)	3.0 (2.0–4.0)	3.0 (2.0-4.0)	2.113	0.053
Indirect bilirubin (μmol/L)	9.0 (6.0–11.0)	9.0 (7.0–12.0)	4.7064	< 0.0014
Triglyceride (mmol/L)	1.10 (0.80–1.58)	1.92 (1.40–2.68)	41.7974	< 0.001
Total cholesterol (mmol/L)	4.75 (0.90)	5.08 (0.96)	15.839	< 0.001
HDL cholesterol (mmol/L)	1.19 (0.29)	1.02 (0.23)	26.529	< 0.001
LDL cholesterol (mmol/L)	2.54 (0.62)	2.63 (0.66)	6.19	< 0.001
Fasting blood glucose (mmol/L)	4.72 (4.44–5.02)	5.04 (4.67–5.56)	26.2504	< 0.0014
Serum uric acid (μmol/L)	317.7 (85.3)	390.8 (83.3)	37.671	< 0.001
Alpha-fetoprotein (μg/L)	2.90 (2.20–3.90)	3.10 (2.40–4.10)	7.6534	< 0.0014

¹n = 7199;

²n = 2601;

³χ² value;

⁴Z value. The data are expressed as the mean ± SD or median (interquartile range) depending on the data distribution. FLD: Fatty liver disease; HDL: High-density lipoprotein; LDL: Low-density lipoprotein.