Connexin 32 and 43 promoter methylation in Helicobacter pylori-associated gastric tumorigenesis

doi:10.3748/wjg.v20.i33.11770

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2014; 20(33): 11770-11779
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11770

Table 5 Methylation levels (%) of Cx32 and Cx43 CpG islands at gastric different stages with Helicobacter pylori infection detected by MassArray method

	Cx32 (9 loci)	Cx43 (8 loci)
NGM without H. pylori infection	55.0 ± 14.9	77.9 ± 16.8
NAG with H. pylori infection	61.2 ± 17.9	86.0 ± 12.5
CAG with H. pylori infection	69.9 ± 16.2	88.6 ± 9.9
IM with H. pylori infection	72.4 ± 19.2^a	89.1 ± 9.6
DYS with H. pylori infection	72.6 ± 19.2^a	90.0 ± 9.3^a
GC with H. pylori infection	76.0 ± 20.1^a	91.6 ± 8.2^a

^aP < 0.05 vs NGM. NGM: Normal gastric mucosa; NAG: Non-atrophic gastritis; CAG: Chronic atrophic gastritis; IM: Intestinal metaplasia; DYS: Dysplasia; GC: Gastric cancer.

Citation: Wang Y, Huang LH, Xu CX, Xiao J, Zhou L, Cao D, Liu XM, Qi Y. Connexin 32 and 43 promoter methylation in Helicobacter pylori-associated gastric tumorigenesis. World J Gastroenterol 2014; 20(33): 11770-11779
URL: https://www.wjgnet.com/1007-9327/full/v20/i33/11770.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i33.11770