Connexin 32 and 43 promoter methylation in Helicobacter pylori-associated gastric tumorigenesis

doi:10.3748/wjg.v20.i33.11770

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2014; 20(33): 11770-11779
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11770

Table 4 Cx32 and Cx43 promoter methylation status at different gastric carcinogenesis stages with Helicobacter pylori infection by bisulfite polymerase chain reaction sequencing method

	n	Cx32 (%)	Cx43 (%)
NGM without H. pylori infection	7	60.1 ± 5.9	75.5 ± 4.3
NAG with H. pylori infection	6	67.3 ± 4.9	82.9 ± 6.3
CAG with H. pylori infection	7	74.5 ± 7.5^a	87.1 ± 5.4^a
IM with H. pylori infection	7	84.2 ± 6.8^a^c^e	90.5 ± 9.3^a^c
DYS with H. pylori infection	6	82.3 ± 6.0^a^c	91.6 ± 8.3^a^c
GC with H. pylori infection	9	85.3 ± 9.7^a^c^e	92.0 ± 7.1^a^c

^aP < 0.05 vs NM;

^cP < 0.05 vs NAG;

^eP < 0.05 vs CAG. NGM: Normal gastric mucosa; NAG: Non-atrophic gastritis; CAG: Chronic atrophic gastritis; IM: Intestinal metaplasia; DYS: Dysplasia; GC: Gastric cancer.

Citation: Wang Y, Huang LH, Xu CX, Xiao J, Zhou L, Cao D, Liu XM, Qi Y. Connexin 32 and 43 promoter methylation in Helicobacter pylori-associated gastric tumorigenesis. World J Gastroenterol 2014; 20(33): 11770-11779
URL: https://www.wjgnet.com/1007-9327/full/v20/i33/11770.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i33.11770