Bovine immunoglobulin protein isolates for the nutritional management of enteropathy

Table 2 Effects of plasma-derived protein concentrates on intestinal function in animal models

Species	Model/indication	Impact of dietary supplementation with SBI	Ref.
Pig	Postweaning	Reduced colonic paracellular permeability	Peace et al[46]
		Reduced ileal permeability
		Fewer lamina propria cells in ileum and colon
		Reduced transepithelial electrical resistance in the colon - improved tight junction
		Significantly improved fecal scores
	Rotavirus infection	Significantly reduced clinical signs of diarrhea	Corl et al[43]
		Significantly greater intestinal mucosal protein and lactase activity
	Infection by ETEC K88	Decreased inflammatory cell infiltration and mucosal damage	Bosi et al[44]
		Increased crypt depth, reduced intestinal expression of proinflammatory TNF-α and IL-8
Rat	Exposure to SEB	Improved ion transport function, as measured by reductions in the potential difference across the jejunum and Na-K-ATPase activity	Pérez-Bosque et al[47]
		Improved mucosal permeability (dextran flux and HRP paracellular flux)

SBI: Serum-derived immunoglobulin/protein isolates; ETEC K88: Enterotoxigenic Escherichia coli, K88 strain; TNF-α: Tumor necrosis factor alpha; IL-8: Interleukin 8; SEB: Staphylococcus aureus enterotoxin B; Na-K-ATPase: Sodium-potassium adenosine triphosphatase; HRP: Horse radish peroxidase.