Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications

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Sep 7, 2014 (publication date) through Dec 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2014; 20(33): 11574-11585
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11574

Table 1 Main genetic and epigenetic alterations in gastric cancer tissues and their clinical application as biomarkers

Alteration	Type of alteration	Clinical application	Ref.
HER-2 amplification	Genetic	Prognostic and therapeutic	[34-40]
MYC amplification	Genetic	Progression and metastasis	[52]
TP53 Arg72Pro	Genetic	Risk predictor, prognostic	[63-67,69-72]
CDH1 -160 C>A	Genetic	Risk predictor	[76-78]
CDH1 hypermethylation	Epigenetic	Prognostic, metastasis	[167,170,171]
p16 hypermethylation	Epigenetic	Diagnostic, prognostic and therapeutic	[156-160]

Citation: Pinheiro DDR, Ferreira WAS, Barros MBL, Araújo MD, Rodrigues-Antunes S, Borges BDN. Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications. World J Gastroenterol 2014; 20(33): 11574-11585
URL: https://www.wjgnet.com/1007-9327/full/v20/i33/11574.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i33.11574