Pancreatic enzyme replacement therapy for pancreatic exocrine insufficiency in the 21st century

Table 6 Recommended clinical trials

Head to head comparisons of different formulations within a product line as well as between commercial products

Comparative trials using different patterns of administration in relation to meals of enteric coated products (e.g., before and during)

Studies combining unprotected and enteric coated preparations

Studies of unprotected preparations combined with maintenance of the intragastric pH constantly above 4

Initial pilot studies using 13C-mixed triglyceride breath testing to test proof of concept may be the most efficient means of identifying which studies to test in human clinical trials