Pancreatic enzyme replacement therapy for pancreatic exocrine insufficiency in the 21st century

Table 3 Currently available United States Food and Drug Administration approved pancreatic enzyme preparations¹

DRUG	Stregth
	Lipase USP	Preparation	Diagmeter\e	pH1	Cost per tablet (United States)	Cost per 1000 units
CREON®
Creon 3000	3000	Capsule with enteric coated minimicrospheres	0.71-1.6 mm	5.5	$1.18	$0.39
Creon 6000	6000	Capsule with enteric coated minimicrospheres	0.71-1.6 mm	5.5	$1.30	$0.22
Creon 12000	12000	Capsule with enteric coated minimicrospheres	0.71-1.6 mm	5.5	$2.32	$0.19
Creon 24000	24000	Capsule with enteric coated minimicrospheres	0.71-1.6 mm	5.5	$4.56	$0.19
Creon 36000	36000	Capsule with enteric coated minimicrospheres	0.71-1.6 mm	5.5	$7.90	$0.22
Pancreaze®
Pancreaze 4200	4200	Capsule with enteric coated microtablets	2 mm	5.5	$0.92	$0.22
Pancreaze 10500	10500	Capsule with enteric coated microtablets	2 mm	5.5	$2.29	$0.22
Pancreaze 16800	16800	Capsule with enteric coated microtablets	2 mm	5.5	$3.68	$0.22
Pancreaze 21000	21000	Capsule with enteric coated microtablets	2 mm	5.5	$4.58	$0.22
Zenpep®
Zenpep 3000	3000	Capsule with enteric coated beads	1.8-1.9 mm	5.5	$1.27	$0.42
Zenpep 5000	5000	Capsule with enteric coated beads	1.8-1.9 mm	5.5	$1.21	$0.24
Zenpep 10000	10000	Capsule with enteric coated beads	2.2-2.5 mm	5.5	$2.39	$0.24
Zenpep 15000	15000	Capsule with enteric coated beads	2.2-2.5 mm	5.5	$3.47	$0.23
Zenpep 20000	20000	Capsule with enteric coated beads	2.2-2.5 mm	5.5	$4.71	$0.24
Zenpep 25000	25000	Capsule with enteric coated beads	2.2-2.5 mm	5.5	$5.83	$0.23
Ultresa®
Ultresa 13800	13800	Capsule with enteric coated minitablet	2 mm	5.5	$3.01	$0.22
Ultresa 20700	20700	Capsule with enteric coated minitablet	2 mm	5.5	$4.46	$0.22
Ultresa 23000	23000	Capsule with enteric coated minitablet	2 mm	5.5	$5.47	$0.24
Pertyze®
Pertyze 8000	8000	Capsule with bicarbonate buffered enteric coated microsphere	0.8-2.2 mm	5.5	$1.99	$0.25
Pertyze 16000	16000	Capsule with bicarbonate buffered enteric coated microsphere	0.8-2.2 mm	5.5	$3.99	$0.25
Viokase®
Viokase 10440	10440	Non-enteric coated			$2.92	$0.28
Viokase 20800	20880	Non-enteric coated			$5.76	$0.28

¹pH at or above which enzyme is designed to release most of the enzyme based on the package insert.