MicroRNA-218 is upregulated in gastric cancer after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy and increases chemosensitivity to cisplatin

Figure 5 Upregulation of miR-218 inhibited gastric tumor growth in vivo. Cells stably expressing miR-218 or miR-NC were incubated in Dulbecco's modified Eagle’s medium and subcutaneously injected into each side of the posterior flank of nude mice (n = 24). Thirty-three days after injection, mice were sacrificed and tumors were removed. A: Tumor volume at 33 d; B: Tumor volumes were detected every three days from the time they were obvious; C: Average tumor weights. ^aDenoted statistical significance between the two groups of miR-218 and control. ^aP < 0.05 vs control.