Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer susceptibility

Table 5 Comparisons of MTHFR C677T and A1298C polymorphisms for gastric cardia and non-cardia cancers, intestinal-type and diffuse-type gastric cancers

	n	Case/control	OR (95%CI)	P	PHeterogeneity	OR (95%CI)	P	PHeterogeneity	OR (95%CI)	P	PHeterogeneity	OR (95%CI)	P	PHeterogeneity
C677T			(TT + CT)/CC			T/C			TT/CC			TT/(CT + CC)
Cardia and non-cardia
Total	7	607/970	0.74 (0.51, 1.08)	0.12	0.01	0.80 (0.59, 1.09)	0.2	0.002	0.82 (0.49, 1.38)	0.46	0.01	0.71 (0.36, 1.39)	0.31	0.06
Eastern	4	418/562	0.76 (0.47, 1.21)	0.24	0.04	0.85 (0.56, 1.27)	0.4	0.01	1.04 (0.52, 2.06)	0.91	0.05	0.89 (0.39, 2.03)	0.78	0.10
Western	3	189/408	0.75 (0.35, 1.61)	0.46	0.04	0.73 (0.45, 1.20)	0.2	0.05	0.59 (0.35, 1.00)	0.05	0.08	0.52 (0.17, 1.59)	0.25	0.26
Intestinal-type and diffuse-type
Total	4	374/340	1.09 (0.74, 1.62)	0.67	0.76	1.10 (0.84, 1.45)	0.5	0.78	1.60 (1.09, 2.35)	0.02	0.87	1.24 (0.68, 2.27)	0.48	0.50
Eastern	1	142/80	1.01 (0.58, 1.74)	0.98	NA	1.03 (0.68, 1.57)	0.9	NA	1.14 (0.44, 2.95)	0.79	NA	1.13 (0.42, 3.04)	0.81	NA
Western	3	232/260	1.19 (0.68, 2.09)	0.55	0.54	1.16 (0.81, 1.66)	0.4	0.57	1.71 (1.13, 2.59)	0.01	0.64	1.32 (0.62, 2.80)	0.48	0.41
A1298C			(CC + AC)/AA			C/A			CC/AA			CC/(AC + AA)
Cardia and non-cardia
Total	2	111/198	0.83 (0.26, 2.64)	0.75	0.03	0.90 (0.34, 2.34)	0.8	0.03	1.87 (0.39, 9.03)	0.44	0.59	1.85 (0.39, 8.69)	0.43	0.75
Eastern	2	111/199	0.83 (0.26, 2.64)	0.75	0.03	0.90 (0.34, 2.34)	0.8	0.03	1.87 (0.39, 9.03)	0.44	0.59	1.85 (0.39, 8.69)	0.43	0.75
Western	0	0	NA			NA			NA			NA

NA: Not available; P_{Heterogeneity}: P value of Q test for heterogeneity test.