Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer susceptibility

Table 4 Comparisons of MTHFR C677T and A1298C polymorphisms for whole and stratified analysis

	n	Case/control	OR (95%CI)	P	PHeterogeneity	OR (95%CI)	P	PHeterogeneity	OR (95%CI)	P	PHeterogeneity	OR (95%CI)	P	PHeterogeneity
			(TT + CT)/CC			T/C			TT/CC			TT/(CT + CC)
C677T
Total	24	6266/8250	1.23 (1.08, 1.40)	0.002	< 0.0001	1.15 (1.06, 1.25)	0.001	0.0004	1.37 (1.15, 1.63)	0.0005	0.0005	1.17 (1.07, 1.28)	0.0008	0.01
Eastern	16	4716/5839	1.26 (1.08, 1.47)	0.003	0.002	1.21 (1.08, 1.34)	0.0005	0.002	1.42 (1.15, 1.76)	0.001	0.005	1.22 (1.09, 1.35)	0.0003	0.03
Western	8	1550/2411	1.20 (0.92, 1.56)	0.180	0.002	1.05 (0.91, 1.21)	0.53	0.05	1.28 (0.91, 1.82)	0.16	0.009	1.05 (0.88, 1.25)	0.55	0.11
Tumor site
Cardia
Total	10	1043/2941	1.09 (0.81, 1.48)	0.560	0.0005	1.16 (0.95, 1.41)	0.14	0.002	1.28 (0.85, 1.95)	0.24	0.003	1.38 (1.15, 1.67)	0.0006	0.05
Eastern	7	854/2416	1.16 (0.89, 1.52)	0.280	0.05	1.24 (1.04, 1.48)	0.02	0.06	1.57(1.23, 2.00)	0.0003	0.16	1.53 (1.25, 1.87)	< 0.0001	0.31
Western	3	189/525	1.09 (0.38, 3.12)	0.870	0.001	1.00 (0.52, 1.91)	1.00	0.004	0.78 (0.15, 4.16)	0.77	0.003	0.73 (0.27, 1.99)	0.54	0.07
Non-cardia
Total	8	1008/1794	1.38 (1.18, 1.63)	< 0.0001	0.42	1.24 (1.10, 1.40)	0.0003	0.42	1.44 (1.09, 1.91)	0.01	0.31	1.19 (0.93, 1.52)	0.16	0.61
Eastern	5	600/1269	1.35 (1.10, 1.66)	0.004	0.99	1.21 (1.04, 1.41)	0.01	0.87	1.30 (0.87, 1.95)	0.20	0.48	1.10 (0.79, 1.55)	0.57	0.44
Western	3	408/525	1.41 (0.83, 2.38)	0.400	0.03	1.26 (0.91, 1.76)	0.16	0.06	1.55 (0.86, 2.78)	0.14	0.12	1.29 (0.91, 1.83)	0.16	0.53
Lauren’s classification
Intestinal
Total	4	374/1504	1.46 (0.86, 2.47)	0.160	0.05	1.33 (0.97, 1.84)	0.08	0.10	1.88 (1.22, 2.89)	0.004	0.19	1.45 (1.07, 1.95)	0.02	0.76
Eastern	1	142/780	1.25 (0.87,1.87)	0.230	NA	1.25 (0.95, 1.64)	0.12	NA	1.71 (0.90, 3.26)	0.10	NA	1.60 (0.86, 2.97)	0.14	NA
Western	3	232/724	1.61 (0.60,4.29)	0.340	0.03	1.37 (0.74, 2.52)	0.32	0.04	2.01 (1.13, 3.59)	0.02	0.07	1.41 (1.00, 1.98)	0.05	0.58
Diffuse
Total	4	340/1504	1.31 (0.66,2.58)	0.440	0.03	1.19 (0.78, 1.82)	0.42	0.06	1.46 (0.66, 3.21)	0.35	0.13	0.94 (0.56, 1.58)	0.82	0.09
Eastern	1	80/780	1.24 (0.78,1.96)	0.360	NA	1.21 (0.85, 1.73)	0.29	NA	1.51 (0.64, 3.57)	0.34	NA	1.40 (0.61, 3.20)	0.80	NA
Western	3	260/724	1.33 (0.35,5.01)	0.670	0.008	1.14 (0.50, 2.60)	0.76	0.02	1.31 (0.29, 5.83)	0.72	0.04	0.85 (0.46, 1.55)	0.59	0.1
A1298C			(CC + AC)/AA			C/A			CC/AA			CC/(AC + AA)
Total	11	2007/3679	0.98 (0.79, 1.21)	0.840	0.008	0.97 (0.83, 1.14)	0.73	0.03	0.95 (0.71, 1.28)	0.76	0.60	0.95 (0.72, 1.27)	0.75	0.78
Eastern	7	1015/1452	0.96 (0.72, 1.29)	0.790	0.02	0.93 (0.73, 1.19)	0.56	0.04	0.44 (0.21, 0.93)	0.03	0.84	0.46 (0.22, 0.96)	0.04	0
Western	4	702/1408	1.00 (0.71, 1.41)	0.990	0.04	1.07 (0.93, 1.23)	0.36	0.15	1.13 (0.82, 1.57)	0.46	0.69	1.11 (0.81, 1.51)	0.53	0.98
Tumor site
Cardia
Total	2	111/267	0.80 (0.37, 1.74)	0.240	0.13	0.83 (0.41, 1.69)	0.61	0.10	0.76 (0.21, 2.83)	0.69	0.28	0.80 (0.22, 2.93)	0.73	0.36
Eastern	2	111/267	0.80 (0.37, 1.74)	0.240	0.13	0.83 (0.41, 1.69)	0.61	0.10	0.76 (0.21, 2.83)	0.69	0.28	0.80 (0.22, 2.93)	0.73	0.36
Western	0	0	NA			NA			NA			NA
Non-cardia
Total	3	236/301	0.98 (0.69, 1.41)	0.930	0.59	0.93 (0.68, 1.26)	0.62	0.69	0.45 (0.15, 1.40)	0.17	0.86	0.46 (0.15, 1.40)	0.17	0.82
Eastern	3	236/301	0.98 (0.69, 1.41)	0.930	0.59	0.93 (0.68, 1.26)	0.62	0.69	0.45 (0.15, 1.40)	0.17	0.86	0.46 (0.15, 1.40)	0.17	0.82
Western	0	0	NA			NA			NA			NA

NA: Not available; P_{Heterogeneity}: P value of Q test for heterogeneity test.