Decreased expression of miR-133a correlates with poor prognosis in colorectal cancer patients

Table 2 Univariate and multivariate analyses for overall survival in colorectal cancer patients

Variable	Univariate analysis				Multivariate analysis
	HR	95%CI	P value		HR	95%CI	P value
Age (yr)	1.107	0.685-1.789	0.679
Sex (male female)	1.154	0.714-1.863	0.559
Tumor location (rectum vs colon)	1.006	0.623-1.625	0.981
Tumor size	1.318	0.814-2.134	0.261
Differentiation	0.788	0.490-1.268	0.326
Local invasion (T3-4 vs T1-2)	4.328	1.780-10.020	0.001		1.196	0.424-3.370	0.735
Lymph node metastasis	2.416	1.488-3.923	< 0.001		0.238	0.033-1.717	0.154
TNM stage	2.336	1.609-3.393	< 0.001		6.111	1.029-36.278	< 0.05
miR-133a expression (high vs low)	0.385	0.232-0.638	< 0.001		0.590	0.350-0.995	< 0.05

TNM: Tumor node metastasis; HR: Hazard ratio.