Role of the 13C-methacetin breath test in the assessment of acute liver injury in a rat model

Table 2 Comparison of biochemical tests and 15-min retention rate of indocyanine green between control group and model groups

Group	ALT (U/L)	TBIL (μmol/L)	PT (s)	ALB (g/L)	ICG15
Control	45.5 ± 7.0	1.36 ± 0.61	13.55 ± 0.55	34.52 ± 2.69	2.8% ± 0.4%
M6h	166.8 ± 40.7	1.56 ± 0.72	18.89 ± 3.38b	33.93 ± 1.27	3.1% ± 0.6%
M12h	444.1 ± 230.4b	2.41 ± 0.98a	23.99 ± 3.09b	33.65 ± 1.57	6.8% ± 1.4%a
M24h	994.3 ± 427.5b	13.74 ± 0.82b	36.36 ± 2.45b	32.08 ± 4.04a	17.0% ± 2.3%b
M48h	436.8 ± 103.7b	12.99 ± 1.67b	33.05 ± 3.22b	31.48 ± 1.57a	11.5% ± 1.6%b
M72h	238.7 ± 70.7	12.81 ± 0.71b	29.13 ± 2.94b	28.79 ± 1.73b	5.7% ± 1.2%

^aP < 0.05,

^bP < 0.01 vs control. ALB: Albumin; ALT: Alanine transaminase; AST: Aspartate transaminase; ICG_R15: The 15-min retention rate of indocyanine green; PT: Prothrombin time; TBIL: Total bilirubin.