MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer

Table 3 MicroRNAs as therapeutic targets in pancreatic cancer

miRNA	Expression	Known target(s)	Function	Ref.
Let-7	↓	KRAS	Inhibition of cell proliferation, chemosensitization	[33,85,86]
miR-10b	↑	TIP30	Increased cell proliferation and invasion	[52]
miR-21	↑		Inhibition of cell proliferation, invasion, tumor growth, chemoresistance and inhibition of apoptosis	[95]
miR-23b			Radioresistance	[91]
miR-29a		Wnt/β-catenin	Chemosensitization to gemcitabine	[88]
miR-34a	↓	Smad3	Inhibition of cell proliferation and invasion, induction of apoptosis	[82,83,94]
miR-96	↓	KRAS	Inhibition of cell proliferation, invasion, tumor growth and induction of apoptosis	[23,70]
miR-99b		mTOR	Radioresistance	[90]
miR-132	↑↓	Rb1	Alteration of cell proliferation	[31,32]
miR-138		lipocalin	Inhibition of tumorigenicity	[93]
miR-141	↓	MAP4K4	Inhibition of cell proliferation and invasion, chemosensitization	[92]
miR-142-3p			Inhibition of cell proliferation	[72]
miR-148a	↓		None	[78]
miR-148b	↓	AMPKα1	Inhibition of cell proliferation, invasion and chemosensitization	[79]
miR-150*		IGF-1R	Induction of apoptosis	[73]
miR-181b	↑	NFkB	Chemosensitization to gemcitabine	[89]
miR-197			Induction of EMT	[75]
miR-198	↓	MSLN, OCT-2, PBX-1, VCP	Inhibition of cell proliferation, invasion, tumor growth and induction of apoptosis	[71]
miR-212	↑	Rb1	Increased cell proliferation	[21]
miR-218	↓		Inhibition of cell proliferation and tumor growth and metastasis	[84]
miR-221	↑		Increased migration, proliferation and EMT	[77]
miR-320c		SMARCC1	Chemosensitization to gemcitabine	[77]
miR-373			Increased tumor growth	[74]
miR-630		IGF-1R	Induction of apoptosis	[73]
miR-655			Inhibition of EMT	[76]

↑: Upregulated; ↓: Downregulated; EMT: Epithelial-mesenchymal transition.