Chronic hepatitis C and liver fibrosis

Table 5 Diagnostic performance of serum biomarkers in chronic hepatitis C

Index	≥F2/F4
	AUC	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	LR+	LR-
Hyaluronan[113-115,119,128]	0.73-0.86/ 0.89-0.92	64.5-75/ 79.2-100	81.0-91.2/ 80.0-89.4	44.0-86.3/ 63.0-100	78.5-93/ 99.0-100	3.94-7.32/ 5.00-7.47	0.30-0.38/ 0.00-0.23
Fibrometer[122,124]	0.85-0.89/ 0.91	80.5-89/ 94.1	84.1-89.9/ 87.6	82.0-86.3/ 68	77.6-82.5/ 94.7	5.56-7.97/ 7.46	0.13-0.21/ 0.06
FibroSpect[122,126-128]	0.82-0.87/ NA	71.8-93.0/ NA	66.0-73.9/ NA	60.9-82.6/ NA	77.7-94/ NA	2.73-2.75/ NA	0.10-0.24/ NA
Hepascore[124,129,130]	0.79-0.85/ 0.85-0.94	53.08-82/ 71.0-76.5	65.0-92.0/ 84.0-89.8	70-88/ 64.9	63.5-78/ 89.6-98	2.34-6.62/ 4.78-6.96	0.27-0.51/ 0.27-0.32
ELF score[122,131]	0.80/ NA	90/ NA	31/ NA	27.5/ NA	92/ NA	1.30/ NA	0.32/ NA
AAR[137,192]	NA/ 0.51-0.83	NA/ 46.7-78.0	NA/ 95.9-100	NA/ 73.7-100	NA/ 80.7-89	NA/ 19.02	NA/ 0.22-0.43
APRI[122,124,133,137,142,192-194]	0.69-0.88/ 0.61-0.94	41-91/ 57-89	47-95/ 75-93	61-88/ 38-57	64-86/ 93-98	1.71-8.20/ 3.56-8.14	0.19-0.62/ 0.10-0.46
Lok Index[137,191]	NA/ 0.78-0.81	NA/ 37-92	NA/ 30-94	NA/ 32-75	NA/ 84-91	NA/ 1.31-6.16	NA/ 0.26-0.67
Forns’ Index[122,124,133,144,192,193]	0.60-0.86/ NA	79.8-94/ NA	61.2-95.0/ NA	66-94.7/ NA	63.8-96/ NA	2.42-15.96/ NA	0.09-0.21/ NA
Fib-4[145]	0.82-0.89/ 0.79-0.91	37.6-74.3/ NA	80.1-98.2/ NA	82.1/ NA	94.7/ NA	3.73-20.77/ NA	0.32-0.63/ NA
Fibrotest[122,124,132,133,135]	0.74-0.87/ 0.71-0.87	65-77/ 50-87	72-91/ 70-92.9	76-80/ 57.9-93	66.7-81/ 44-90.5	2.75-7.22/ 2.9-7.04	0.31-0.38/ 0.17-0.53

AUC: Area under the curve; NA: Not available; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; AAR: AST-to-ALT ratio; APRI: AST-to-platelet ratio index.