Involvement of eicosanoids in the pathogenesis of pancreatic cancer: The roles of cyclooxygenase-2 and 5-lipoxygenase

Figure 3 Metabolic pathway of arachidonic acid via 5- lipoxygenase. Arachidonic acid is released from membrane phospholipids by phospholipase A₂ and converted to 5-HPETE by 5-LOX and 5-LOX activating protein (FLAP). 5-HPETE can then form either 5-HETE or LTA₄. LTA₄ then becomes LTB₄ or LTC₄. LTC₄ can then form LTD₄ and subsequently LTE₄. cPLA2: Cytosolic phospholipase A₂; LOX: Lipoxygenase; FLAP: 5-LOX activating protein; HPETE: Hydroperoxyeicosatetraenoic acid; HETE: Hydroxyl 6 trans 8, 11, 14 cis eicosatetraenoic acid; LT: Leukotriene.