Age-related differences in response to peginterferon alfa-2a/ribavirin in patients with chronic hepatitis C infection

doi:10.3748/wjg.v20.i31.10984

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 21, 2014; 20(31): 10984-10993
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10984

Table 3 Rates of dose modification n (%)

	All genotypes		P value	OR (95%CI)	Genotype 1		P value	OR (95%CI)
	< 60 yr(n = 4558)	≥ 60 yr(n = 301)		OR (95%CI)	< 60 yr(n = 2614)	≥ 60 yr(n = 245)	P value	OR (95%CI)
No dose reduction	3933 (86.3)	208 (69.1)	P value	0.000	2.814 (2.172-3.644)	2204 (84.3)	166 (67.8)	0.000	2.558 (1.918-3.412)
Reduction of RBV	286 (6.3)	55 (18.3)	0.000	1.827 (1.560-2.140)	190 (7.3)	47 (19.2)	0.000	1.74 (1.460-2.074)
Reduction of	224 (4.9)	20 (6.6)	0.183		129 (4.9)	17 (6.9)	0.173
pegINF α2a	224 (4.9)	20 (6.6)	0.183		129 (4.9)	17 (6.9)	0.173
Reduction of RBV and pegINF α2a	115 (2.5)	18 (6.0)	0.001	1.349 (1.138-1.600)	91 (3.5)	15 (6.1)	0.039	1.218 (1.010-1.470)

Rates of dose modification: Comparison of patients < 60 years vs≥ 60 years with chronic hepatitis C. RBV: Ribavirin; pegIFN: Pegylated interferon.

Citation: Roeder C, Jordan S, Schulze zur Wiesch J, Pfeiffer-Vornkahl H, Hueppe D, Mauss S, Zehnter E, Stoll S, Alshuth U, Lohse AW, Lueth S. Age-related differences in response to peginterferon alfa-2a/ribavirin in patients with chronic hepatitis C infection. World J Gastroenterol 2014; 20(31): 10984-10993
URL: https://www.wjgnet.com/1007-9327/full/v20/i31/10984.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i31.10984