Role of endoscopic ultrasound in the molecular diagnosis of pancreatic cancer

Table 3 Main studies investigated expression of Mucin and molecular markers for the diagnosis of pancreatic cancer using endoscopic ultrasound-guided fine needle aspiration materials

Molecular markers	Methods for analysis	Sensitivity (%)	Specificity (%)	Accuracy (%)	Ref.
MUC1+/MUC2-/MUC5AC+	IHC	70	100	75	70
CytoP + MUC5AC	IHC	90	93	91	71
CytoP + MUC1		85	100	89
MSLN, UPAR	qRT-PCR	100	94	-	77
S100P	IHC	90	90	87	78
MSLN		62	74	66
S100P + KRT7	qRT-PCR	80	77	-	23
cytoP alone	qRT-PCR	68/88	100/90	75/89	73
cytoP alone/cytoP + S100A6

CytoP: Cytopathology; IHC: Immunohistochemistry; qRT PCR: Quantitative reverse transcription polymerase chain reaction; MUC: Mucin; MSLN: Mesothelin; UPAR: Urokinase plasminogen activator receptor.