Role of endoscopic ultrasound in the molecular diagnosis of pancreatic cancer

Table 1 Main studies investigating Kras mutation assay on specimens obtained by endoscopic ultrasound-guided fine-needle aspiration for the differential diagnosis between pancreatic carcinoma and pseudo-tumorous chronic pancreatitis

Ref.	Patient	Sensitivity (%)	Specificity (%)	Overall accuracy (%)
	PC/CP	Cytopathology alone/Kras + cytoP	Cytopathology alone/Kras + cytoP	Cytopathology alone/Kras + cytoP
Tada et al[31]	28/8	62/81	100/100	71/85
Pellisé et al[35]	33/24	97/97	100/100	84/98
Takahashi et al[34]	62/15	84/94	100/100	CytoP alone: 58
Maluf-Filho et al[33]	57/11	82/90	97/47	59/89
Bournet et al[28]	129/27	83/88	100/100	72/90
Reicher et al[30]1	34/16	88	94	90
Ogura et al[29]	307/47	87/93	100/100	89/94
Ginestà et al[32]	43/18	76/86	100/100	82/90
Bournet et al[39]2	104/72	71/90	100/99	84/94

¹Combination of Kras + cytoP + FISH/Fluorescence in situ hybridization; ²PC vs others malignant and benign pancreatic lesions. PC: Pancreatic carcinoma; CP: Chronic pancreatitis; CytoP: Cytopathology.