Clinical mycophenolic acid monitoring in liver transplant recipients

Table 1 Pharmacokinetic data of mycophenolic acid in adult liver transplant recipients

Ref.	Year	Regimen	Time since LT	n	Method	AUC0-12h (mg.h /L)	Mean tmax (h)	Mean C0h (mg/L)	Mean Cmax (mg/L)
Jain et al[65]	2001	TAC + MMF	Days 6-30	8	HPLC	40.0 ± 30.9 (7.3-102.3)	1.8 ± 1.6		10.6 ± 7.5
Mardigyan et al[92]	2005	TAC + MMF	> 12 mo	14	EMIT	45 ± 22	0.5	2.1 ± 1.5	12.2 ± 75
Pisupati et al[60]	2005	TAC + MMF	< week 1	10	HPLC	50.8 ± 42.1	1.8 ± 1.2		9.1 ± 7.2
			Weeks 1-2			60.3 ± 38.5	1.8 ± 1.4		11.6 ± 6.7
			Weeks 3-6			118.0 ± 57.6	1.3 ± 0.7		36.7 ± 15.6
Brunet et al[11]	2006	TAC + MMF	Day 6	13	HPLC-UC	17.4 (13.2-39.7)	2	0.4	4.6
			Day 16	13		26.3 (13.1-45.8)	1.2	0.6	7.7
			Month 3	14		33.6 (15.1-54.6)	0.7	1.3	6.6
Chen et al[71]	2007	TAC + MMF	Day 7	38	HPLC	44.6 ± 16.50 (17.99-96.87)	1.42 ± 0.77		8.45 ± 4.77
			Day 14	34		50.54 ± 18.60 (22.78-98.73)	1.45 ± 0.81		11.29 ± 5.51
Chen et al[76]	2008	TAC + MMF	Days 7-14	48	EMIT	45.77 ± 18.69 (10.66-117.01)	1.94 ± 1.65	2.02 ± 1.57	11.76 ± 6.34
Kamar et al[93]	2009	TAC + MMF	Day 7	15	HPLC	36.8 ± 27
			Day 14	15		32.6 ± 11
			Day 30	15		36.7 ± 13
Beckebaum et al[94]	2009	TAC + MMF	Day 60 (14-230 d)	18	LC-MS/MS	55.9 (22.9-144.8)	0.5	3	14.2
		CsA + MMF	Day 70 (11-87 d)	12		52.2 (31.8-102.1)	1	2.5	15.3
Benichou et al[61]	2010	TAC + MMF	Day 12 (4-20 d)	26	EMIT	26.8 (21.8-39.7)
			Day 36 (24-90 d)	25		45.2 (26.0-57.0)

TAC: Tacrolimus; MMF: Mycophenolate mofetil; CsA: Cyclosporine A; HPLC: High-performance liquid chromatography; EMIT: Enzyme multiplied immunoassay technology.