Human liver stem/progenitor cells decrease serum bilirubin in hyperbilirubinemic Gunn rat

Figure 3 Injected Gunn rat follow up. A: Assessment of bilirubin concentration stability in 11 naive rats of the Gunn rat colony followed during 27 wk. Bilirubin concentration is expressed in mg/dL; B: Mean of unconjugated bilirubin for adult-derived human liver stem/progenitor cells (ADHLSC) injected rats n = 4 (black line), human hepatocytes injected rats n = 3 and for negative control n = 3 (grey line). Difference between 2 wk and 27 wk post injection concentration bilirubin was significant for ADHLSC injected rats (P = 0.0032). Mean of unconjugated bilirubin (UCB) concentration is expressed in mg/dL. Squares: hADHLSC; Triangles: human hepatocytes; Inverted triangles: negative controls; C: Unconjugated bilirubin evolution with time. Black lines: ADHLSC transplanted Gunn rats n = 5; dotted lines: PBS injected rats n = 3 (negative control). Bilirubin concentration is expressed in mg/dL.