Length of negative resection margin does not affect local recurrence and survival in the patients with gastric cancer

Table 3 Survival-related factors in early gastric cancer

Clinicopathologic factors	Univariable analysis for OS (P value, HR)	Multivariable analysis for OS (P value, HR)	Univariable analysis for RFS (P value, HR)	Multivariable analysis for RFS (P value, HR)
Sex	0.094, 0.438		0.117, 0.373
Age	< 0.001, 1.086	< 0.001, 1.081	0.848, 1.004
Size of the tumor	0.003, 1.267	0.124, 1.158	0.018, 1.253	0.515, 1.079
Operation method	0.270, 1.185		0.618, 0.599
Lymphatic invasion	< 0.001, 5.289	0.077, 2.437	< 0.001, 13.310	< 0.001, 7.689
Vascular invasion	0.219, 3.503		0.002, 10.119	0.046, 0.208
Perineural invasion	0.005, 5.642	0.173, 2.416	0.027, 5.229	0.492, 0.580
WHO classification	0.760, 0.886		0.441, 0.683
Lauren classification	0.593, 0.783		0.601, 0.754
Harvested lymph node	0.676, 0.994		0.658, 1.007
Positive lymph node	< 0.001, 1.065	0.164, 1.038	< 0.001, 1.078	0.006, 1.068
PM	0.405, 0.930		0.592, 1.049
DM	0.609, 1.025		0.235, 0.916
Stage	< 0.001, 10.515	0.028, 3.836	< 0.001, 16.028	0.168, 2.416

Age, size of the tumor, harvested lymph node, positive lymph node, PM, DM were included as continuous values in this analysis. EGC: Early gastric cancer; OS: Actual 3-year overall survival; RFS: Actual 3-year recurrence-free survival; PM: The length of proximal resection margin; DM: The length of distal resection margin.