Caspase-1 inhibition alleviates acute renal injury in rats with severe acute pancreatitis

Table 2 Intrarenal expression of caspase-1, interleukin-1β and interleukin-18 mRNAs

Group	n	Caspase-1	IL-1β	IL-18
HC	6	0.36 ± 0.03	0.13 ± 0.01	0.38 ± 0.03
SAP-S
6 h	6	0.45 ± 0.03b	0.19 ± 0.02b	0.57 ± 0.04b
12 h	6	0.46 ± 0.04b	0.20 ± 0.03b	0.58 ± 0.05b
18 h	5	0.43 ± 0.04b	0.20 ± 0.03b	0.55 ± 0.04b
SAP-ICE-I
6 h	6	0.45 ± 0.03b	0.15 ± 0.02d	0.45 ± 0.04bd
12 h	6	0.44 ± 0.03b	0.15 ± 0.02d	0.45 ± 0.04bd
18 h	5	0.45 ± 0.02b	0.15 ± 0.02d	0.44 ± 0.04bd

Values are mean ± SD;

^bP < 0.01 vs HC;

^dP < 0.01 vs SAP-S. HC: Healthy controls; SAP: Severe acute pancreatitis; SAP-ICE-I: SAP with IL-1β-converting-enzyme inhibition; SAP-S: SAP with saline.