Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C

doi:10.3748/wjg.v20.i30.10449

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 14, 2014; 20(30): 10449-10456
Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10449

Table 8 Adipokines and single nucleotide polymorphisms of interleukin 28B in chronic hepatitis C

	CC (n= 6)		TT/CT (n= 25)		Pvalue
	Median (LQ-UQ)	Min-max	Median (LQ-UQ)	Min-max
SOCS-3	11.52 (3.164-15.738)	2.17-17.95	5.10 (1.75-8.713)	0.5-24.537	P > 0.05
HCV viremia (IU/mL)	1195000 (362000-3830000)	112000-9850000	3780000 (799000-4290000)	382000-7210000	P > 0.05
ALT (U/L)	54 (43-83)	23-339	45 (44-47)	41-48	P > 0.05
HOMA	(1.02-3.99)	0.78-5.66	2.44 (1.5-2.84)	0.88-9.67	P > 0.05
Adiponectin (μg/mL)	7.56 (6-8.37)	5.33-9.07	6.35 (5.34-8.89)	3.51-18.48	P > 0.05
Osteopontin (ng/mL)	24.33 (22.18-32.98)	13.14-34.58	29.94 (16.79-37.78)	5.33-59.15	P > 0.05
Visfatin (ng/mL)	2.64 (1.57-6.35)	0.65-9.33	2.56 (1.13-5.69)	0.45-9.37	P > 0.05
Leptin (ng/mL)	13.11 (8.56-17.2)	5.47-39.04	3.04 (1.69-11.94)	0.77-54.65	P > 0.05
Omentin (ng/mL)	367.16 (257.55-399.91)	152.74-522.77	390.95 (341.39-536.18)	115.7-757.34	P > 0.05
Resistin (ng/mL)	1.17 (0.91-1.65)	0.76-1.74	1.55 (1.205-1.83)	0.73-2.92	P > 0.05

The single nucleotide polymorphisms (SNPs) of IL28B (rs 12979860) were not associated with adipokine levels or HOMA-IR index. Genotypes of IL28B: CC and not CC (CT and TT); SOCS-3: Suppressor of cytokine signaling 3; HOMA-IR: Homeostasis model assessment of insulin resistance; ALT: Alanine aminotransferase; LQ: Lower quartile; UQ: Upper quartile.

Citation: Wójcik K, Jabłonowska E, Omulecka A, Piekarska A. Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C. World J Gastroenterol 2014; 20(30): 10449-10456
URL: https://www.wjgnet.com/1007-9327/full/v20/i30/10449.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i30.10449