Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C

doi:10.3748/wjg.v20.i30.10449

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 14, 2014; 20(30): 10449-10456
Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10449

Table 3 Adipokines and liver steatosis in chronic hepatitis C

	With steatosis (n= 10)		Without steatosis (n= 21)		Pvalue
	Median (LQ-UQ)	Min-max	Median (LQ-UQ)	Min-max
SOCS3	6.553 (3.393-11.777)	1.042-24.537	5.106 (2.095-8.713)	0.5-17.95	P > 0.05
HOMA	2.815 (1.99-4.84)	1.25-9.67	1.995 (1.21-2.51)	0.78-7.25	P = 0.05
Adiponectin (μg/mL)	5.985 (4.83-7.23)	3.55-8.43	8.37 (5.71-9.07)	3.51-18.48	P = 0.047
Osteopontin (ng/mL)	33.51 (15.52-49.12)	5.33-59.15	24.7 (18.26-34.58)	11.57-47.85	P > 0.05
Leptin (ng/mL)	5.705 (3.04-17.2)	2.34-54.65	3.825 (1.33-13.11)	0.77-39.04	P > 0.05
Resistin (ng/mL)	1.65 (1.42-1.84)	1.17-2.36	1.51 (1.03-1.58)	0.73-2.92	P > 0.05
Omentin (ng/mL)	374.875 (332.79-483.33)	227.99-757.34	393.92 (360.09-522.77)	115.7-735.84	P > 0.05
Visfatin (ng/mL)	2.465 (1.37-3.12)	0.45-3.97	2.64 (1.17-4.08)	0.53-9.37	P > 0.05

Hepatic steatosis was related to increased HOMA-IR index (2.81 vs 1.99, P = 0.05) and reduced adiponectin level (5.96 vs 8.37, P = 0.04). SOCS-3: Suppressor of cytokine signaling 3; HOMA-IR: Homeostasis model assessment of insulin resistance; LQ: Lower quartile; UQ: Upper quartile.

Citation: Wójcik K, Jabłonowska E, Omulecka A, Piekarska A. Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C. World J Gastroenterol 2014; 20(30): 10449-10456
URL: https://www.wjgnet.com/1007-9327/full/v20/i30/10449.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i30.10449