Helicobacter pylori eradication in West Asia: A review

Table 3 Randomized controlled trials for Helicobacter pylori eradication in Turkey

Ref.	Type of patients	Type of triple therapy regimens	Number of patients in each study arm	Eradication rate (%)
				Per-protocol	Intention-to-treat
Aydin et al[29], 2007	PUD + NUD	PAC-14, PAC-7	40-40	73.5-47.1	67.6-44.4
Yaşar et al[33], 2010	Dyspepsia	PAC-14, PAC-14 with probiotic	38-38	53-66	53-66
Uygun et al[32], 2004	Dyspepsia	LAC-14, PAC-14	45-45	69.2-70	62.2-60
Sezikli et al[31], 2012	NUD	LAC-14, LAT-14	40-40	47.4-39.3	45-37.5
Aladağ et al[28], 2005	DU	OAC-14, PAC-14	64-62	90.6-93.5	90.6-93.5
Erçin et al[75], 2011	DU	LALevo-7, LALevo-14	51-40	34.1-72.7	27-65
Seven et al[76], 2004	PUD-NUD	OALevo-10, OALevo-10[half dose]	50-60	72.7-60	72.7-60
Gumurdulu et al[30], 2004	PUD	OAC-7 , OAC-14, OBTM-10	53-59-52	NA	24.5-40.6-61.5
Alkim et al[34], 2011	PUD + NUD	OAC-14, LAC-14, RAC-14, PAC-14, EAC-14, RBAC-14	66-66-66-66-66-66	65.6-72.1-84.4-62.5-60.3-85.7	63.6-66.7-81.8- 60.6-57.6-81.8
Songür et al[35], 2009	PUD, NUD	LAC-14, LMT-10, LBMT-10, RLBMT-10	113-115-119-117	35.6-64.4-54.9-64.6	32.7-60-47.1-57.3
Uygun et al[36], 2007	NUD	LAC-14, LBMT-14	120-120	62.7-82.3	57.5-70
Kadayifci et al[56], 2012	NUD	EABT-14, EAMT-14	100-100	89.7-80.4	79-74
Sezgin et al[55], 2006	PUD + NUD	RBMT-14, PBMT-14	42-40	61.9-55	61.9-55
Uygun et al[57], 2007	NUD	RBAT-14, RBAC-14, RBMT-14	100-100-100	64.4-66.2-58.9	58-59-56
Akyildiz et al[53], 2009	PUD + NUD	RBAT-14, RBADox-14	58-57	40.8-45.7	34.5-36.8
Köksal et al[54], 2013	Dyspepsia	OBTM-14 ,	45 - 45	86.8-90.1	73.3-89.9
		OBTM-14[Optimal dose]
Nadir et al[37], 2011	Dyspepsia	LA-MT-14, LAC-14,	144-138	77.6-53.6	72.2-52.5
Yakut et al[71], 2010	Dyspepsia	PA-MT-10, RaBAC-14	108-75	88-95	88-95
Uygun et al[39], 2008	NUD	PA-MT-14, PAC-14	150-150	80.1-63	72.6-58
Cetinkaya et al[70], 2010	NUD	PA-MT-14, PA-TM-14 (HYBRID)	56-56	83.6-81.4	82.1-78.5
Polat et al[38], 2011	NUD	E-A-[first 7 d]-LevoM-[last 7 d]-14, EAC-14	75-75	90-57	86.6-50.6

O: Omeprazole; E: Esomeprazole; B: Bismuth; Ra: Ranitidine; A: Amoxicillin; C: Clarithromycine; L: Lansoprazole; P: Pantoprazole; T: Tetracycline; M: Metronidazole; R: Rabeprazole; Levo: Levofloxacine; NA: Not available; PUD: Peptic ulcer disease; NUD: Non-ulcer dyspepsia.