Optimizing clarithromycin-containing therapy for Helicobacter pylori in the era of antibiotic resistance

Table 3 Efficacy of sequential and concomitant therapy, with a duration of 10 to 14 d, on dual clarithromycin-metronidazole resistant Helicobacter pylori strains n (%)

Ref.	Treatment duration (d)	Patients	Eradication rates
Concomitant therapy
Wu et al[61], Thailand, 2010	10	4	3 (75)
Huang et al[62], China, 2012	10	2	2 (100)
Molina-Infante et al[63], Spain, 2012	10	4	3 (75)
Molina-Infante et al[65], Spain-Italy, 2013	14	3	3 (100)
Georgopoulos et al[66], Greece, 2013	10	10	7 (70)
Total		23	18 (78)
Sequential therapy
Vaira et al[39], Italy, 2007	10	4	0 (0)
Liou et al[52], Taiwan, 2013	14	8	3 (37)
Wu et al[61], Thailand, 2010	10	3	1 (33)
Huang et al[62], China, 2012	10	4	2 (50)
Molina-Infante et al[63], Spain, 2012	10	5	3 (60)
Romano et al[70], Italy, 2010	10	3	0 (0)
Total		27	9 (33)

Adapted from Georgopoulos et al[71], with permission.