FOLFOX/FOLFIRI pharmacogenetics: The call for a personalized approach in colorectal cancer therapy

Table 2 Putative biomarkers of efficacy and/or toxicity of oxaliplatin in colorectal cancer

Gene	Transcript	Protein	SNP	Effect	Ref.
ATP7B	Low	Low	-	Longer PFS	Martinez-Balibrea et al[78] 2009
ABCB1	No association	-	-	DFS and OS	Hlavata et al[28] 2012
	-	-	AG genotype in rs1045642	Longer DFS	Wu et al[79] 2013
	-	-	AA genotype in rs1128503	Longer OS	Wu et al[79] 2013
	-	-	AA-GG-TT haplotype in rs1045642-rs1128503-rs2032582	Shorter PFS and OS	Wu et al[79] 2013
ERCC1	High	-	-	Shorter OS	Shirota et al[80] 2001
	High	-	-	Shorter OS	Grimminger et al[81] 2011
	-	High	-	Shorter DFS and OS	Huang et al[82] 2013
	-	No association	-	PFS and OS	Koopman et al[49] 2009
	-	-	GG genotype in rs11615	Longer OS	Huang et al[83] 2011
	-	-	Rs11615	No association with OS	Martinez-Balibrea et al[84] 2011
ERCC2	-	No association		DFS and OS	Huang et al[110] 2013
	-	-	Variant allele in rs1052559	Shorter OS	Le Morvan et al[86] 2007
XRCC1	-	No association		DFS and OS	Huang et al[82] 2013
	-	-	CC genotype in rs25487	Longer OS	Huang et al[83] 2011
GSTM1 deletion	-	-	One copy	Longer OS	Funke et al[87] 2010
	-	-	Null genotype	Higher neutropenia	McLeod et al[90] 2010
GSTP1	-	-	AA genotype in rs1695	Inferior response	Kumamoto et al[88] 2013
	-	-	Rs1695	No association	Funke et al[87] 2010
	-	-	Rs1695	No association	Huang et al[85] 2008
	-	-	Rs1695	No association	Le Morvan et al[86] 2011
	-	-	AA genotype in rs1695	Higher neurotoxicity	McLeod et al[90] 2010
	-	-	Rs1695	No association with toxicity	Peng et al[91] 2013
GSTT1	-	-	Deletion	No association	Funke et al[87] 2010
	-	-	Deletion	No association	Huang et al[85] 2008
	-	-	Deletion	No association	Le Morvan et al[86] 2011

PFS: Progression-free survival; DFS: Disease free survival; OS: Overall survival.