Implications of biomarkers in human hepatocellular carcinoma pathogenesis and therapy

Table 3 MicroRNAs deregulated in hepatocellular carcinoma

miRNAs	Expression in HCC	Target	Involvement in cellular processes
miR-199	Down	Met, mTOR, PAK4, DDR1, caveolin-2	Proliferation, autophagy, metastasis, invasion; autophagy, drug resistance; cell growth[95]
miR-449	Down	c-Met	Proliferation; apoptosis[97]
miR-122	Down	Bcl-w, ADAM-1, Wnt-1	Apoptosis; metastasis; angiogenesis[100-102]
miR-34a	Down	c-Met; CCL22	Metastasis[103]
miR-200a	Down	HDAC4	Proliferation; metastasis[104]
miRs-let-7a, -7b, -7c, -7d, -7f-1	Down	Caspase-3, HMGA2, C-myc, Bcl-xl	Proliferation, apoptosis[112]
miR-125a, -125b	Down	MMP11, SIRT7, VEGF-A, LIN28B2, Bcl-2, Mcl-1, Bcl-w	Angiogenesis, apoptosis, metastasis, proliferation[115,116]
miR-29	Down	SPARC	Proliferation[114]
miR-224	Up	RKIP; CDC42; CDH1; PAK2; BCL-2; MAPK1; API-5	Metastasis; proliferation; apoptosis[113]
miR-519d	Up	CDKN1A/p21; PTEN; AKT3; TIMP2	Proliferation; invasion; apoptosis[109]
miR-216a	Up	TSLC1,PTEN	Tumorigenesis[107]
miR-148a	Up	PTEN	Tumorigenesis[108]
miR-21	Up	PTEN, RhoB, PDCD4	Drug resistance, metastasis[105,106]
miR-221	Up	Bmf, DDIT4, Arnt, CDKN1B/p27, CDKN1C/p57	Angiogenesis, apoptosis, proliferation[98,99]

HCC: Hepatocellular carcinoma.