Implications of biomarkers in human hepatocellular carcinoma pathogenesis and therapy

Table 2 Clinical relevance of deregulated microRNAs in hepatocellular carcinoma

Molecular alteration	miRNAs	Clinical significance
Down regulation	miR-139	Poor survival[70]
	miR-26	Shorter overall survival[82-87]
	miR-124	Gain of metastatic properties early recurrence[69]
	miR-145	Advanced tumor progression, poor prognosis[71]
	miR-199a-3p	Reduced time to recurrence[72]
	miR-199b-5p	Poor overall survival and Progression-free survival rates[72]
	miR-122	Poor prognosis[82-87]
Up regulation	miR-222	Shorter disease-free survival[73]
	miR--135	Poor prognosis worse Edmondson-Steiner grade, vein invasion, shortened overall survival and disease-free survival[74]
	miR-221	Multinodularity, reduced time to recurrence, gain of metastatic properties high tumor capsular infiltration[79]
	miR--155	Poorer recurrence-free survival and overall survival[75]
	miR--182	Intrahepatic metastasis and poor prognosis[76]
	miR- 10b	Poor prognosis[77]
	miR-17-5p	Poor prognosis[78]
	miR-21	Poor prognosis[79]