Current management of hepatocellular carcinoma

Table 5 Selection criteria for transplantation in hepatocellular carcinoma

Ref.	No. of patients	Selection criteria	Survival rate at 5 yr
Mazzaferro et al[18] 1996	48	Milan criteria: single HCC < 5 cm or up to 3 nodules < 3 cm	75% (4 yr)
Yao et al[19] 2001	70	UCSF criteria: a maximum tumor size of 6.5 cm or 2 lesions ≤ 4.5 cm in diameter with a total tumor diameter of ≤ 8 m	75%
Kwon et al[86] 2007	114	HCC ≤ 5 cm	87%
		AFP ≤ 400 ng/mL
Lee et al[87] 2008	186	Up to 6 nodules with a maximum diameter of < 5 cm	76%
Mazzaferro et al[21] 2009	283	Up to 7 criteria: 7 as the sum of the largest size (cm) and the number of tumors	71%
Herrero et al[88] 2001	154	HCC ≤ 6 cm or ≤ 3 HCC ≤ 5 cm	73%
Jonas et al[89] 2007	21	Any number, each ≤ 6 cm with cumulated diameter ≤ 15 cm	62% at 3 yr
Toso et al[90] 2008	288	TTV ≤ 115 cm3	72%
Sugawara et al[91] 2007	78	≤ 5 HCC ≤ 5 cm	70% at 3 yr

TTV: Total tumor volume; HCC: Hepatocellular carcinoma; AFP: Alpha-fetoprotein; UCSF: University of California, San Francisco.